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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Correction: CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma

Fig. 8

CD147 promotes cathepsin B via β-catenin signaling. a-b. Western blot analysis of indicated proteins in Huh-7 (a) and HepG2 (b) cells transfected with indicated constructs. c-d. Quantitative real-time PCR analysis of CTSB expression in Huh-7 (c) and HepG2 (d) cells transfected with indicated constructs. *** p < 0.0001, one-way ANOVA. e-f. Western blot analysis of indicated proteins in Huh-7 (b) and HepG2 (f) cells transfected with indicated siRNAs or treated with TWS119. G. Metastasis assay by intra-splenic injection of indicated cells in nude mice. Livers were excised for examination (left panel). Graph shows quantitative analysis of intrahepatic metastasis. * p < 0.05, ** p < 0.01, one-way ANOVA. h. Kaplan-Meier survival curves of HCC patients stratified into double positive- and double negative-expression of CD147 and cathepsin B according to immunohistochemical staining. i. Schematic representation of the major mechanisms of CD147 regulating collective invasion in hepatocellular carcinoma

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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