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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation

Fig. 8

Evaluation of antitumor immunity induced by Pt@PCN-Cu and αPD-L1 combined therapy in vivo. (A, B) Representative flow cytometry plots and corresponding percentages of CD8⁺ T cells in tumor tissues from mice subjected to various treatments. (C, D) Representative flow cytometry plots and corresponding percentages of Tregs in tumor tissues from mice subjected to various treatments. (E-G) Representative flow cytometry plots and corresponding percentages of m-MDSCs and pmn-MDSCs in tumor tissues from mice subjected to various treatments. (H-J) Serum levels of inflammatory cytokines (IL-6, TNF-α and IFN-γ) measured using ELISAs. Data are presented as mean ± SD. Statistical significance was determined using a one-way ANOVA, with **P < 0.01 and ***P < 0.001

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