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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation

Fig. 7

Combined treatment with Pt@PCN-Cu and αPD-L1 enhances in vivo antitumor efficacy. (A) Schematic representation of the treatment schedule, with arrows indicating the time points of intravenous injections. (B) Representative photographs of tumors excised from different treatment groups. (C) Tumor growth curves of mice subjected to different treatments. (D) Ex vivo tumor weights measured at the end of the study. (E, F) Representative images of H&E staining (E) and Ki67 staining (F) of tumor tissues from mice treated with different regimens. Scale bar: 100 μm–50 μm. Data are presented as mean ± SD. Statistical significance was determined using one-way ANOVA, with ***P < 0.001

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