Fig. 4

Induction of apoptosis in SEC cell lines at different concentrations of SN-38 and rucaparib. A) and C), cells were cultured with continuous exposure to the indicated drug concentrations for 4 days, stained with propidium iodide in sodium citrate (A) or Annexin V (C), and subjected to flow microfluorimetry. Error bars indicate mean \(\:\pm\:\) SEM of 3–4 independent experiments. B) and D), combination index (CI) for the SN-38 + rucaparib drug combination. Different shapes indicate results from each of 3–4 independent experiments