Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Advanced organoid models for targeting Kras-driven lung adenocarcinoma in drug discovery and combination therapy

Fig. 7

Effect of Midostaurin, Decitabine, and their combination on cell cycle and apoptosis in Kras-driven LUAD organoids. A Cell cycle distribution of KP organoids analyzed by flow cytometry after treatment with midostaurin, decitabine, and their combination, using 7AAD/saponin staining. B Quantitative summary showing the percentage of cells in different phases of the cell cycle. C Flow cytometric analysis of cell death in treated KPC organoids stained with Annexin V/7AAD to distinguish live, early apoptotic, late apoptotic, and necrotic populations. D Graphical representation (%) of live and apoptotic populations following treatments. E Immunofluorescence staining for cleaved caspase to confirm apoptosis induction after drug treatments.Mido: midostaurin, Deci: decitabine

Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us