Fig. 4

Organoids preserve the histopathological features of parental tumors. (A) Representative H&E staining of KP, KPC, and KPC-LM tumors together with H&E staining of the organoids. Scale bar, 100 μm. H&E; hematoxylin & eosin. B) Histopathological characterization of murine tissue and organoids by LUAD nuclear marker TTF-1 and cytoplasmic marker CK7, and proliferation marker Ki67. Representative images show the results of immunofluorescence staining. TTF-1, CK7 and Ki67 expression are shown individually and merged with DAPI (blue). TTF1; Thyroid transcription factor-1, CK7; Cytokeratin 7, Ki67: Antigen Kiel 67