Fig. 2

Palbociclib modulates the activation/expression of cell cycle-related proteins in a dose- and time-dependent manner. MDA-MB-231 and HCC38 cells were treated with increasing concentrations of palbociclib for 24 h (a) or with a fixed drug concentration for different periods of time (b). The expression of the indicated proteins was analyzed by Western blotting. Results are representative of three independent experiments