Table 2 TAMs differentiation under the influence of tumor microenvironment

BC

MCT-1/miR-34a/IL-6/IL-6R

Pro-M2 polarization

Promote EMT and stemness

[55]

MiR-138-5p /KDM6B

Anti-M1 + Pro-M2 polarization

Promote metastasis to the lung

[56]

Lactate/Gpr132

Pro-M2 polarization

Facilitate tumor adhesion, migration, and invasion

[57]

Lactate/HIF-1α/STAT3

Pro-M2 polarization

Lead to endocrine therapy resistance

[58]

MiR-200c/PAI-2 q15.6

Pro-M2 polarization

Promote the cell migration ability

[59]

PS/MERTK/STAT3/JMJD3/IRF4

Pro-M2 polarization

Promote tumor growth

[60]

Ovarian cancer

CircITGB6/IGF2BP2/FGF9

Pro-M2 polarization

Mediate resistance to cisplatin

[61]

CircATP2B4/miR-532-3p/SREBF1/PI3Kα/AKT

Pro-M2 polarization

Promote tumor metastasis

[62]

ETS1/αvβ5/AKT/Sp1

Pro-M2 polarization

Promote omental metastasis

[63]

LCA

CSF1R/AKT

Pro-M2 polarization

Suppress antitumor immune responses

[64]

Src/CD155/MIF

Pro-M2 polarization

Facilitate distant metastasis

[65]

Succinate/SUCNR1/PI3K-HIF-1α

Pro-M2 polarization

Promote tumor metastasis

[66]

PIM1/NF-κB/CCL2/CCR22

Pro-M2 polarization

Promote tumor progression and immune evasion

[67]

MiR-19b-3p/PTPRD/STAT3

Pro-M2 polarization

Promote tumor metastasis

[68]

MiR-21-5p/PTEN

Anti-M2 polarization

Attenuate apoptotic and promote metastasis

[69]

GC

TLR4/PI3K/Akt

Pro-M2 polarization

Increase the migration and invasion abilities

[70]

PLXNC1/MEK1/MSK1/CREB1/miR-92b-5p/STAT3

Pro-M2 polarization

Promote tumor growth

[71]

CircATP8A1/miR-1-3p/STAT6

Pro-M2 polarization

Promote proliferation and migration

[72]

HCC

AKT/Ras

Pro-M2 polarization

Impair enrichment of cytotoxic T cells

[73]

MiR-206/KLF4/NF-κB

Pro-M1 polarization

Enhance expansion and migration of CD8 + T cells

[73]

CRC

PKN2/DUSP6-Erk1/2

Anti-M2 polarization

Inhibit tumor growth

[74]

SPON2/integrin β1/PYK2

Pro-M2 polarization

Promote tumor growth and metastasis

[75]

IL10R/Wnt5a/CaMKII/ERK/STAT3/IL-10

Pro-M2 polarization

Promote tumor growth and metastasis

[76]

CTSK/TLR4/PI3K/AKT/mTOR

Pro-M2 polarization

Promote migration and motility ability of CRC cells

[77]

HnRNPA1miR-106a-5pJAK2/STAT3

Pro-M2 polarization

Promote CRC liver metastasis

[78]

circPOLQ/miR-379-3p/IL-10/STAT3

Pro-M2 polarization

Promote tumor invasion and migration

[79]

PC

FGD5-AS1/p300/STAT3/NF-κB

Pro-M2 polarization

Promote tumor progression

[80]

Lactate/Gpr132

Pro-M2 polarization

Support growth and metastasis

[81]

ANXA2/MMP28/MAPK/JNK/IL-8

Pro-M2 polarization

Promote tumor growth and migration

[82]

Melanoma

IL-1R-MYD88-Tet2

Pro-M2 polarization

Attract MDSCs

[83]

NPC

USP7/TRIM24/SPLUNC1

Pro-M1 polarization

Repress tumor growth and migration

[84]

HNSCC

miR-9/PPARδ/NF-κB

Pro-M1 polarization

Increase the radiosensitivity of HPV + HNSCC

[85]

GBM

SLIT/ROBO/PI3K-γ

Pro-M2 polarization

Facilitate glioma growth and vascular dysmorphia

[38]