Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy

Fig. 1

The origin and evolution of TAMs. TAMs stem from bone marrow-derived circulating monocytes and embryonic tissue-resident macrophages (TRM). Regulatory molecules (including CCL2, CCL5, CCL7, CCL16, CCL20, CXCL8, CXCL12, CSF, IL-1β, IL-6, IL-17, IL-33, IL-34, TGF-β, TNF, PGE2, VEGF, PDGF and SLIT2) induce the recruitment of monocytes/macrophages to tumor tissues. Upon recruitment to the TME, these cells are stimulated by various signals to polarize into M1 or M2-like macrophages and then exhibit diverse functions

Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us