Fig. 7

Targeting c-FOS treatment can inhibit tumor growth and lung metastasis. A The luminescence intensity of tumor cells grown in mice treated with targeted c-FOS (T5224) or NETs (DNase I). B, C Tumor volumes were determined on the indicated days with different treatments in 4T1 mice (n = 5). D Immunohistochemical staining detects the expression levels of Ly6G protein in mouse tumor tissues. E IF detects the expression levels of MPO (red), CitH3 (pink), and c-FOS (green) proteins in mouse tumor tissues. F Luminescence intensity of lung metastatic tumor cells in mice treated with targeted c-FOS or NETs. G Lung metastasis nodules of the 4T1 tumor were measured after treatment. H Immunohistochemical staining detects the expression levels of Ly6G protein in mouse lung metastatic tumor tissues. I IF detects the expression levels of MPO (red), CitH3 (pink), and c-FOS (green) proteins in mouse lung metastatic tumor tissues. Data are presented as means from three independent experiments ± S.D. **P < 0.01; ***P < 0.001; ****P < 0.0001