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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence

Fig. 8

Sh-TRAF7 and Lomustine (CCNU) synergistically inhibit glioma tumor growth. A Schematic illustration of the experimental design for the glioma orthotopic implantation model, and evaluation of brain tumor growth after injection CCNU. B Bioluminescence images of nude mice bearing glioma orthotopic xenograft (n = 5) were shown on days 14, 21, 28, 35, and 42. The nude mice were inoculated with U251 cells transfected with luciferase, divided into six groups: (1) Control, (2) Control + CCNU, (3) sh-TRAF7, (4) sh-TRAF7 + CCNU, (5) OE-TRAF7, (6) OE-TRAF7 + CCNU. The crossing in the blank area indicated that the corresponding mouse had died. C-D Survival curves of glioma-bearing mice, with median survival times listed in the accompanying table. E Quantitative analysis of bioluminescence. F The curves of body weight in nude mice

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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