Fig. 4

HVEM-Fc could eradicate the tumor cells by activating T cells in NSCLC organoids and T cell co-culture models. Notes: A-C The 8 μg/mL HVEM-Fc group yielded the strongest anti-tumor effect and the anti-tumor effect was more pronounced at 5 days; D At 120 h, bright field and fluorescent images were taken; E ELISA detection of perforin in the supernatants of cell culture medium; F-N T cell proliferation and activation were analyzed through flow cytometry; O-R The 8 μg/mL HVEM-Fc group had the strongest anti-tumor effect in lung adenocarcinoma organoids and T cell co-culture model