Fig. 5

Association between tumor methylation and immune phenotypic profiles and survival in the TCGA-MESO cohort. Gene set enrichment analysis of the differentially expressed (DE) genes in the hyper-methylated (CIMP) and the hypo-methylated (LOW) tumor samples from PM patients of the TCGA-MESO cohort. The top 20 biological processes (BP) enriched in CIMP (yellow) or in LOW (blue) were shown (A). Tumor microenvironment deconvolution of immune and stromal cell fractions in CIMP (yellow) and LOW (blue) PM tissues from the TCGA-MESO cohort’ patients (B). Kaplan–Meier curve of the OS of CIMP (yellow; #37) and LOW (blue; #36) TCGA patient’s cohort (C). Statistical analysis was performed by the Log-rank (Mantel-Cox) test