Fig. 3

The anti-tumor effect of VSIG4⁺ TAMs inhibition is depended on CD8 ⁺ T cells. (A) Scheme of animal experiments to evaluate the effects of lymphocyte depletion on tumor growth in VSIG4-KO mice. 1 × 10⁶ Panc02 cells were injected subcutaneously on day 0, and 100 µg CD4 depletion antibody, 100 µg CD8 depletion antibody, 50 µg NK depletion antibody were administered on day 1, 3 and 5. The tumor growth curve (B), tumor size (C) and tumor weight (D) of each group were recorded. Tumors were isolated on day 19, and n = 5 for each group. Data are presented as mean ± S.E.M