Fig. 8

Identifying potential small-molecule activators of PANoptosis in GBM. A-C Differential expression gene (DEG) volcano plots showing DEGs between the high and low PANoScore groups in the TCGA-GBM-IDHwt, CPTAC-GBM-IDHwt, and PRJNA482620-GBM-IDHwt cohorts. D UpSet plot illustrating common DEGs across the three cohorts. E Chord diagram visualizing the functional enrichment analysis of common DEGs. F Candidate small-molecule compounds and their mechanisms of action predicted through the Connectivity Map (CMap) database and Mechanism of Action (MOA) analysis