Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content

Table 1 Patient Characteristics and Comparison between Low Collagen and High Collagen

From: Extracellular matrix stiffness regulates colorectal cancer progression via HSF4

Characteristics

All Patients (N = 107)

Low Collagen (N = 50)

High Collagen (N = 57)

P-value

Sex

 Male

62

28

34

0.85

 Female

45

22

23

 

Age (year)

56.92 ± 10.83

56.96 ± 12.19

56.88 ± 9.58

0.97

Height (m)

1.62 ± 0.07

1.61 ± 0.08

1.62 ± 0.07

0.44

Weight (kg)

59.76 ± 11.54

57.47 ± 11.32

61.76 ± 11.45

0.05

BMI (kg/m2)

22.74 ± 3.35

22.03 ± 3.30

23.35 ± 3.29

0.041*

Stiffness Characteristics

 Shear Wave Velocity of Normal Tissue (m/s)

1.28 ± 0.13

1.27 ± 0.12

1.29 ± 0.14

0.46

 Shear Wave Velocity of Tumour Tissue (m/s)

2.30 ± 0.56

2.18 ± 0.46

2.41 ± 0.61

0.028*

 Ratio of Tumour/Normal

1.80 ± 0.39

1.72 ± 0.31

1.88 ± 0.43

0.031*

MRI Characteristics

 mT

    

 mT1

2

0

2

0.041*

 mT2

23

13

10

 

 mT3

66

34

32

 

 mT4

16

3

13

 

mN

 mN0

49

24

25

0.08

 mN1

38

21

17

 

 mN2

20

5

15

 

mM

 mM0

100

48

52

0.45

 mM1

7

2

5

 

Circumferential Resection Margin

 Positive

15

5

10

0.40

 Negative

92

45

47

 

Extramural Vascular Invasion;

 Positive

28

8

20

0.029*

 Negative

79

42

37

 

Tumour Growth Pattern

 Intramural

32

21

11

0.013*

 Luminal

64

27

37

 

 Both

11

2

9

 

 Tumour Length (mm)

43.53 ± 16.72

40.62 ± 14.97

46.09 ± 17.86

0.09

 Tumour Thickness (mm)

15.39 ± 7.89

13.34 ± 4.98

17.19 ± 9.44

0.009**

MRI Cancer Nodule

 Positive

10

3

7

0.33

 Negative

97

47

50

 

Hyperintensity on T2w images

 Positive

14

10

4

0.08

 Negative

93

40

53

 

Vascular Edema, Necrosis or Mucous Degeneration

 Positive

20

9

11

1.00

 Negative

87

41

46

 

Hemorrhage, High T1

 Positive

2

2

0

0.21

 Negative

105

48

57

 

Number of Mesorectal Lymph Nodes

 0

48

24

24

0.11

 1

14

9

5

 

 2

22

11

11

 

 > = 3

23

6

17

 

Histopathologic features

pT or ypT

 Tis

7

0

7

0.06

 T1

10

7

3

 

 T2

24

10

14

 

 T3

63

31

32

 

 T4

3

2

1

 

pN or ypN

 N0

68

30

38

0.67

 N1

32

17

15

 

 N2

7

3

4

 

TNM stage or ypTNM stage

 0

7

0

7

0.001**

 I

16

11

5

 

 II

27

19

8

 

 III

51

18

33

 

 IV

6

2

4

 

Cancer Nodule

 Positive

12

5

7

0.76

 Negative

95

45

50

 

Perineural Invasion

 Positive

15

6

9

0.78

 Negative

92

44

48

 

Vascular Invasion

 Positive

18

9

9

0.80

 Negative

89

41

48

 

Histologic Grade

 Low

13

6

7

0.07

 Moderate

82

42

40

 

 High

2

1

1

 

 Unassessable or Missing

10

1

9

 

Mismatch Repair Status

 Deficient Mismatch Repair

9

6

3

0.20

 Proficient Mismatch Repair

76

37

39

 

 Unassessable or Missing

22

7

15

 

Progression

 Locally advanced rectal cancer

84

39

45

1.00

 Non-locally advanced rectal cancer

23

11

12

 

Survival Status

 Alive

86

50

57

0.027*

 Deceased

21

5

16

 

 Average Survival Time (months)

58.63 ± 1.61

60.52 ± 1.34

54.63 ± 2.64

0.019*

  1. Notes: This table comprehensively presents the demographic, clinical, and histopathologic characteristics of all patients (N = 107), stratified by collagen levels into the Low Collagen (N = 50) and High Collagen (N = 57) groups. Categorical variables were compared using Chi-square tests, while continuous variables were analysed with student's t-tests (or suitable non-parametric tests, where applicable, when normality assumptions were violated). Abbreviations used throughout the table include MRI (Magnetic Resonance Imaging) for imaging traits, BMI (Body Mass Index) for anthropometric measurements, and pT, pN, and TNM for pathological staging. Abbreviations mT, mN, and mM refer to MRI-based tumour, node, and metastasis staging. In this study, a P-value less than 0.05 was considered statistically significant. An asterisk (*) signifies a statistically significant difference (p < 0.05), while a double asterisk (**) indicates a higher level of significance (e.g., p < 0.01)
Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us