Fig. 9

The inhibition of the MIF and p-STAT3 pathways effectively suppresses the growth of OSCC. A, B and C In vivo, inhibition of MIF and p-STAT3 can reduce tumor size. D and E Flow cytometry results demonstrate that inhibition of MIF and p-STAT3 decrease the number of CD74⁺ PDGFRB⁺ cells. F and G Flow cytometry results show that inhibition of MIF and p-STAT3 increase the number of CD8⁺ T cells. H and I Flow cytometry results show that inhibition of MIF and p-STAT3 decrease the number of CD4⁺ T cells. Statistics are shown in mean ± SD (C, E, G and I) accessed by the unpaired t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, nonsignificant, respectively