Fig. 1

CCR8 is highly expressed in tumor tissues of HCC patients and associated with poor prognosis. A The expression level of CCR8 in primary tumor tissues and normal tissue from TCGA. B Quantification of CCR8 positive cells between the tumor tissues and corresponding paratumor tissues of HCC patients (n = 90). C The expression of CCR8 in paratumor tissues and tumor tissues from each HCC group was assessed by IHC analysis. Scale bar: 50 μm. D The Kaplan–Meier survival analysis plot showing a significant association between CCR8 expression and overall survival of HCC patients. E The proportion of different grades of HCC patients in CCR8 high and low groups. Data were shown as mean ± SD. *p < 0.05, ***p < 0.001, ****p < 0.0001, compared to control