Fig. 2

Effects of the NAT10 inhibitor Remodelin on CRC proliferation. A. WB analysis of NAT10 expression in a panel of CRC cell lines treated with Remodelin. B. CCK-8 assay of SW48 and SW620 cells treated with different concentrations of Remodelin. C. The correlation between the basal NAT10 expression content and Remodelin efficacy. D, E. EdU and colony formation assays were performed to verify the effect of Remodelin on CRC cell proliferation. The data are representative of three independent experiments and presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, determined using two-tailed unpaired Student’s t-tests