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Table 1 Histopathological analysis of colon samples

From: E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration

Sample

Diagnosis

Hyperplasia/GIN

Adenoma/Adenocarcinoma

Inflammation

GALT

Distribution

Macroscopic growth pattern

Herniation (Y/N)

Histotype

Grade of dysplasia (high/low)

Mitotic count

Ulcer (Y/N)

Type

Severity (1–3)

Extent

Edema (0–3)

Hyperplasia (0–3)

PBS_1

Normal

       

L

1

Diffuse

0

0

PBS_2

Normal

       

L

1

Diffuse

0

0

PBS_3

Normal

       

L

1

Diffuse

0

0

PBS_4

Normal

       

L

1

Diffuse

0

0

PBS_5

Normal

       

L

1

Diffuse

1

0

DSS_1

Inflamation

Diffuse

      

LP

1

Diffuse

1

2

DSS_2

Inflamation/Hyperplasia

Diffuse

      

LP

1

Diffuse

0

2

DSS_3

Inflamation/Hyperplasia

Diffuse

      

LP

2

Diffuse

1

2

DSS_4

Inflamation

Diffuse

      

LP

2

Diffuse

1

2

DSS_5

Inflamation/Hyperplasia

Diffuse

      

LP

2

Diffuse

1

2

DSS_6

Inflamation/Hyperplasia

Diffuse

      

LP

1

Diffuse

1

1

DSS_7

Inflamation/Hyperplasia

Diffuse

      

LP

1

Diffuse

1

1

DSS_8

Inflamation

Diffuse

      

LP

1

Diffuse

2

1

CNF1/DSS_1

GIN + Sq. metaplasia

Diffuse (GIN) focal (Metaplasia)

 

N

    

LPH

2

Diffuse

2

2

CNF1/DSS_2

Adenoma + GIN

Diffuse (GIN) focal (adenoma)

broad-based

N

Tubular

low

15

Y

LPHN

2

Diffuse

2

1

CNF1/DSS_3

Adenoma + GIN

Diffuse (GIN) focal (adenoma)

broad-based

N

Tubular

low

9

N

LPHN

2

Diffuse

1

1

CNF1/DSS_4

GIN

Diffuse

 

N

    

LPH

2

Diffuse

1

2

CNF1/DSS_5

GIN

Diffuse

 

N

    

LPH

2

Diffuse

1

2

CNF1/DSS_6

GIN + Adenoma

Diffuse + Focal (adenoma)

broad-based

N

Tubular

low

5

N

LPH

3

Diffuse

1

2

CNF1/DSS_7

Adenoma

Focal

broad-based

N

Tubular

low

5

N

LPH

2

Diffuse

2

2

CNF1/DSS_8

GIN + Sq. metaplasia

Diffuse

 

N

   

Y

LPHN

2

Diffuse

2

2

CNF1_1

Normal

       

L

1

Diffuse

1

0

CNF1_2

Hyperplasia

Diffuse

      

LP

1

Diffuse

1

0

CNF1_3

Hyperplasia

Diffuse

      

LP

1

Diffuse

1

0

CNF1_4

Hyperplasia

Diffuse

      

LP

1

Diffuse

1

0

CNF1_5

Hyperplasia

Diffuse

      

LP

1

Diffuse

1

0

CNF1_6

Normal

       

L

1

Diffuse

1

0

CNF1_7

Normal

       

L

1

Diffuse

1

0

CNF1_8

Hyperplasia

Diffuse

      

LP

1

Multifocal

1

1

  1. Legend: GIN = gastrointestinal intraepithelial neoplasia; inflammation type L = lymphocytic, LP = lymphoplasmacytic, H = histiocytic, N = neutrophilic; inflammation severity 1 = mild (scarse inflammatory cells confined to the lamina propria), 2 = moderate (moderate inflammatory cells confined to the lamina propria), 3 = severe (inflammatory cells involving the submucosa); edema 0 = absent, 1 = mild (confined to the lamina propria), 2 = moderate (confined to the lamina propria), 3 = severe (involving the submucosa); gastrointestinal-associated lymphoid tissue (GALT) hyperplasia 0 = absent, 1 = mild, 2 = moderate, 3 = severe
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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