Table 4 Univariate and multivariate Cox analyses for overall survival of the mPDAC cohort according to clinical characteristics and cCAF and plasma HA levels
Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
Variable | N | HR (95% CI) | P-value | HR (95% CI) | P-value |
Total cCAFs | 22 | 1.057 [1.020–1.095] | 0.002 | 1.047 [1.001–1.096] | 0.046 |
HA > 148.2 ng/ml (vs. ≤ 148.2 ng/ml) | 10/14 | 3.651 [1.419–9.392] | 0.007 | 1.656 [0.526–5.214] | 0.389 |
CA19-9 ≥ 500 kU/l (vs. < 500 kU/l) | 17/10 | 3.601 [1.178–11.011] | 0.025 | 3.657 [0.680–19.666] | 0.131 |
Age ≥ 75 years (vs. < 75 years) | 6/21 | 2.989 [1.108–8.063] | 0.031 | ||
Sex (Female vs. male) | 13/14 | 0.719 [0.303–1.706] | 0.455 | ||
ECOG ≥ 2 (vs. 0–1) | 6/21 | 7.584 [2.449–23.485] | < 0.001 | ||
Liver metastasis (Yes vs. no) | 15/12 | 1.505 [0.609–3.718] | 0.376 | ||
Peritoneum metastasis (Yes vs. no) | 10/17 | 2.080 [0.839–5.154] | 0.114 | ||
Prior lines of chemotherapy (0 vs. ≥ 1) | 8/19 | 0.899 [0.347–2.333] | 0.828 | ||