Table 2 Different proposed bs-Abs for targeting TNFR2 and different immunosuppressive molecules and receptors
From: Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer
Bs-Abs | Target antigen | Cell type | Function | Format |
|---|---|---|---|---|
TNFR2A × TNFR2B, TNFR2A × TNFR2C and TNFR2B × TNFR2C | TNFR2 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signal of TNFR2. Prevent clustering of TNFR2 units | 1 + 1 |
Mb-TNFαA × Mb-TNFαB, Mb-TNFαA × Mb-TNFαC and Mb-TNFαB × Mb-TNFαC | TNFR2 and Mb-TNFα | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the interaction between membrane-bound-TNFR2 and Mb-TNFα | 1 + 1 |
TNFR2 × EGFR | TNFR2 and EGFR | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and EGFR | 1 + 1 |
TNFR2 × CTLA-4 | TNFR2 and CTLA-4 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and CTLA-4 | 1 + 1 |
TNFR2 × PD-L1/PD-1 | TNFR2 and PD-L1 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and PD-L1/PD-1 | 1 + 1 |
TNFR2 × VEGFR | TNFR2 and VEGFR | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of VEGF (trap) | 1 + 1 |
TNFR2 × CD20 | TNFR2 and CD20 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and CD20 | 1 + 1 |
TNFR2 × TGFβR2 | TNFR2 and TGFβR2 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of TGFβ (trap) | 1 + 1 |
TNFR2 × CD3ε | TNFR2 and CD3ε | BC cells, CD8+ T cells | Block the signals of TNFR2 and activate CD8+ T cells (T cell engager) | 1 + 1 |
TNFR2 × NK cell activating receptors | TNFR2 and NK cell activating receptors | NK cells, BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and activate NK cells (NK cell engager) | 1 + 1 |
TNFR2 × LAG-3 | TNFR2 and LAG-3 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and LAG-3 | 1 + 1 |
TNFR2 × CXCR-3 | TNFR2 and CXCR-3 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of CXCR-3 ligands | 1 + 1 |
TNFR2 × CXCR-4 | TNFR2 and CXCR-4 | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of CXCL-12 | 1 + 1 |
TNFR2 × IL-4R | TNFR2 and IL-4R | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of IL-4 (trap) | 1 + 1 |
TNFR2 × IL-6R | TNFR2 and IL-6R | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of IL-6 (trap) | 1 + 1 |
TNFR2 × IL-10R | TNFR2 and IL-10R | BC cells, BCSCs, MDSCs, T-regs, B-regs, CAFs, MCSs, EPCs | Block the signals of TNFR2 and block the binding of IL-10 (trap) | 1 + 1 |
TNFR2 × E2 receptors | TNFR2 and E2 receptors | BC cells | Block the signals of TNFR2 and block the binding of PEG2 | 1 + 1 |