Fig. 7
From: The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma
Effects of FGF/FGFR blockade in MM cells. FGF/FGFR inhibitors block the FGF/FGFR/c-Myc axis by activating GSK-3β kinase that rapidly induces the degradation of the oncoprotein c-Myc which in turn causes GSH depletion, mitochondrial oxidative stress, DNA damage, cell cycle arrest and eventually apoptosis of MM cells