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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice

Fig. 9

Immunohistochemistry analysis of Ki67 and PCNA on lung metastasis from Bio-nFeR versus control mice. (A) Left: Representative IHC images of Ki67-positive nuclei on lung metastasis from Bio-nFeR versus vehicle mice; Right: Proliferation index by Ki67 staining in treated and control metastases; (B) Left: Representative IHC images of PCNA-positive nuclei in lung metastases from Bio-nFeR versus vehicle mice; Right: Proliferation index by PCNA nuclear staining in treated and control metastases. Quantifications were obtained by analyzing images at 20x magnification. Proliferation index was calculated by automated pixel counting, as the ratio between Ki67-or PCNA-positive/total nuclei (see Methods and Additional file: Fig. S5). Magnifications 5x and 20x, scale bares 200 and 50 μm, respectively

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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