Exosomal miR-106a-5p from highly metastatic colorectal cancer cells drives liver metastasis by inducing macrophage M2 polarization in the tumor microenvironment

Table 1 Correlation of plasma exosomal miR-106a-5p level with clinicopathological factors in CRC patients (n = 104)

Variables	Patients	miR-106a-5p expression		χ²	P value
Variables	(n = 104)	High (n = 52)	Low (n = 52)	χ²	P value
Gender				0.979	0.322
Male	59	27 (51.9)	32 (61.5)
Female	45	25 (48.1)	20 (38.5)
Age (years)				3.126	0.077
≤ 60	49	20 (38.5)	29 (55.8)
> 60	55	32 (61.5)	23 (44.2)
Tumor location				1.418	0.234
Colon	44	19 (36.5)	25 (48.1)
Rectum	60	33 (63.5)	27 (51.9)
Tumor diameter (cm)				2.719	0.099
≤ 5	68	30 (57.7)	38 (73.1)
> 5	36	22 (42.3)	14 (26.9)
Tumor differentiation				4.872	0.027
Poor	41	26 (50.0)	15 (28.8)
Well / Moderate	63	26 (50.0)	37 (71.2)
pT stage				1.846	0.174
T1-2	26	16 (30.8)	10 (19.2)
T3-4	78	36 (69.2)	42 (80.8)
pN stage				0.038	0.844
N0	51	26 (50.0)	25 (48.1)
N1-2	53	26 (50.0)	27 (51.9)
Distant metastasis				4.265	0.039
M0	79	35 (67.3)	44 (84.6)
M1	25	17 (32.7)	8 (15.4)
pTNM stage				0.639	0.424
I-II	42	19 (36.5)	23 (44.2)
III-IV	62	33 (63.5)	29 (55.8)
CEA (ng/ml)				2.556	0.110
≤ 5	62	27 (51.9)	35 (67.3)
> 5	42	25 (48.1)	17 (32.7)
CA19-9 (U/ml) ^#				1.049	0.306
≤ 27	67	31 (59.6)	36 (69.2)
> 27	37	21 (40.4)	16 (30.8)
Lymphatic/microvascular/perineural invasion				7.278	0.007
Yes	35	24 (46.2)	11 (21.2)
No	69	28 (53.8)	41 (78.8)

* Defined by basic CEA or/AND CA19-9, CT or/AND MRI, or PET-CT
# The cut-off value is determined based on the diagnostic cut-off values utilized at our hospital
P values in bold indicate P < 0.05

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