Fig. 7

NAT10 contributed to glycolysis elevation and T-cell inhibition by upregulating JunB expression. A Quantification of lactate production in control and remodelin treatment of mice serum. B Quantification of lactate production in the supernatant. C-F Glycolytic stress tests using the Seahorse XF bioanalyzer to measure the glycolysis level, glycolytic capacity, and reserve. G, H Primary T cell was incubated with CM from NAT10-Kd or JunB-OE cells. T-cell activation was detected by flow cytometry. The data are shown as the means ± SDs; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001