Fig. 4

The loss of NAT10 facilitates T cell infiltration and activation. A, B T-cell cytotoxicity test by colony formation assay, and survival relative to the control is shown. C, D CM from NAT10-Kd cells were used to culture Jurkat and primary T cells, and ELISA detected IL-2 secretion. E–G Intracellular cytokine staining of IL-2, TNFα, and IFN-γ of T cell after co-culture with CM from NAT10-Kd cells. The data are shown as the means ± SDs; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001