Fig. 1

NAT10 Plays a Potential Oncogenic Role in TNBC. A RNA-seq detected NAT10 expression in 15 normal tissues (N) and 15 tumor tissues (T) of breast cancer. B, C IHC detected NAT10 protein expression from 134 breast cancer patients in the HMUCC cohort, including 18 Luminal A subtypes, 41 Luminal B subtypes, 37 HER2 subtypes, and 38 TNBC subtypes. D qRT-PCR detected NAT10 expression in normal tissues (N) and tumor tissues (T) of TNBC. E NAT10 expression in four molecular types of 821 breast cancers in the TCGA database, including 421 Luminal A subtypes, 192 Luminal B subtypes, 67 HER2 subtypes, and 141 TNBC subtypes. F Kaplan–Meier analysis of overall survival of TNBC patients according to NAT10 expression by using KM plotter (https://kmplot.com/analysis/index.php?p = service&cancer = breast_rnaseq_gse96058). The data are shown as the means ± SDs; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001