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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Enhancer looping protein LDB1 modulates MYB expression in T-ALL cell lines in vitro by cooperating with master transcription factors

Fig. 7

MBZ demonstrates anticancer effects both in vivo and in vitro. A CCK-8 assays detected the effects of MBZ. Robust inhibition of tumor cell growth in all four T-ALL cell lines. B Western blotting analysis showed that MYB, PARP and GAPDH protein pression in 6 T-CEM and J.gamma1 cells after the effects of MBZ. Robust inhibition. C Flow cytometry revealed that MBZ treatment induced more apoptotic cells in a dose-dependent manner. D Relevant bioluminescence imaging of D12, D26 and D32 days in MBZ group and control group. E Histogram shows the bioluminescence signal values for both groups of mice at different time points. F Mice of the MBZ group exhibited prolonged survival time compared to the vechile group. G Different sizes and weights of liver and spleen, from the MBZ group and vechile group

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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