Fig. 1

Upregulation of LDB1 in T-ALL patients and its correlation with poor clinical characteristics. A Data from the GEO dataset GSE13159 revealed a significantly higher mRNA expression of LDB1 in T-ALL patients compared to bone marrow samples from healthy donors. B Analysis of the Cancer Cell Line Encyclopedia (CCLE) database revealed an overexpression of LDB1 in T-ALL cell lines compared to other cancer types. C Our center's sequencing data of T-ALL patients demonstrated a statistically higher expression of the LDB1 gene in patients with a high bone marrow tumor burden. D CRISPR screen data indicated the dependence of T-ALL cell line Jurkat on LDB1. E CCK-8 assay detected the proliferation rate of Jurkat cell. F Western blot assay for LDB1 protein expression in acute leukemia cell lines and Healthy Donor T Cells