Table 1 Highly dysregulated and statistically significant miRNAs (-2 > FC > 2; p-value < 0.05) detected in RMS patients compared to HCs, in ERMS and ARMS patients compared to HCs and in ARMS patients compared to ERMS patients

ERMS

ARMS

RMS

ANOVA p-value

RMS vs HC

ERMS vs HC

ARMS vs HC

ARMS vs ERMS

hsa-miR-483-5p

7.72 ± 3.62

18.34 ± 4.59

11.9 ± 4.09

0.007

0,002

0.016

0.002

0.284

hsa-miR-132-3p

2.83 ± 1.61

3.45 ± 1.57

3.12 ± 1.57

 < 0.001

0,000

0.000

 < 0.001

0.495

hsa-miR-766-3p

2.9 ± 3.28

2.75 ± 2.72

2.83 ± 2.82

0.046

0,011

0.026

0.030

0.938

hsa-miR-454-3p

2.3 ± 1.99

2.6 ± 2.34

2.45 ± 2.08

0.030

0,007

0.023

0.015

0.808

hsa-miR-197-3p

2.4 ± 2.03

2.13 ± 1.79

2.26 ± 1.85

0.006

0,001

0.003

0.005

0.752

hsa-miR-335-3p

3.01 ± 1.812

12.87 ± 2.62

6.23 ± 2.93

0.001

0,009

0.053

 < 0.001

0.007

hsa-miR-17-5p

1.17 ± 4.39

5.51 ± 1.38

2.54 ± 3.66

0.006

0,026

0.161

0.002

0.022

hsa-miR-486-5p

-1.54 ± 2.07

3.2 ± 1.33

1.44 ± 2.69

 < 0.001

0,062

0.447

 < 0.001

 < 0.001

hsa-miR-484

-1.01 ± 1.75

2.98 ± 1.31

1.72 ± 2.04

0.001

0,031

0.205

 < 0.001

0.002