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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling

Fig. 6

Reducing FIS1 and MFF inhibited mitochondrial division, while the overexpression had the opposite effect. a Western blot, expressions of mitochondria-related proteins in the U87MG when FIS1 was down-regulated and overexpressed. b Statistical analysis of Western blot after regulation of FIS1. c Representative images of electron microscopy after down-regulation and overexpression of FIS1 (U87-sh-FIS1-NC, n = 6; U87-sh-FIS1, n = 6; U87-OE-FIS1-NC, n = 6; U87-OE-FIS1, n = 6). Scale bars: 0.5 µm. d Statistical analysis of the mitochondrial size, density and shape after regulation of FIS1 (U87-sh-FIS1-NC, n = 105; U87-sh-FIS1, n = 93; U87-OE-FIS1-NC, n = 115; U87-OE-FIS1, n = 108). e Western blot, expressions of mitochondria-related proteins in the U87MG when MFF was down-regulated and overexpressed. f Statistical analysis of Western blot after regulation of MFF. g Representative images of electron microscopy after down-regulation and overexpression of MFF (U87-sh-FIS1-NC, n = 6; U87-sh-FIS1, n = 6; U87-OE-FIS1-NC, n = 6; U87-OE-FIS1, n = 6). Scale bars: 0.5 µm. h Statistical analysis of the mitochondrial size, density and shape after regulation of MFF (U87-sh-MFF-NC, n = 72; U87-sh-MFF, n = 85; U87-OE-MFF-NC, n = 86; U87-OE-MFF, n = 98). The data were presented as means ± SD. P were calculated by unpaired two-tailed t-test (b, f) or Mann-Whitney U test (d, h)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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