Table 2 Clinical spectrum of disease in KC and KCH−/− mice
From: Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
Age (weeks) | Sex | Genotype | Pancreas histology | Muc.papil | Lymph. prol.dis | Other pathological features |
|---|---|---|---|---|---|---|
20 | ♂ | KC | ADM; PanIN-1 and 2 | + | - | splenomegaly |
26 | ♀ | KC | ADM; PanIN-1, 2, and rare 3 | + | + | splenomegaly |
28 | ♂ | KC | ADM; PanIN-1 and 2, rare 3 | + | - | - |
28 | ♀ | KC | ADM; PanIN-1 | + | - | - |
28 | ♂ | KC | PanIN-3; early PDAC | - | - | - |
29 | ♀ | KC | ADM; PanIN-1 and 2 | + | - | - |
30 | ♂ | KC | ADM; PAnIN-1, rare 2 | + | - | - |
30 | ♂ | KC | ADM; PanIN-1, rare 3 | - | + | lung mass |
31 | ♀ | KC | ADM; PanIN-1, 2 and 3 | + | - | splenomegaly |
44 | ♂ | KC | PanIN-3; cystic PDAC | + | - | - |
44 | ♀ | KC | ADM; PanIN-1 and 2 | + | - | splenomegaly |
45 | ♂ | KC | ADM; PanIN-3 | + | + | lung mass |
13 | ♀ | KCH−/− | normal pancreatic tissue | - | + | thymic and lung masses |
14 | ♀ | KCH−/− | normal pancreatic tissue | - | + | thymic mass |
14 | ♂ | KCH−/− | ADM; PanIN-1 | - | + | splenomegaly; lung mass |
18 | ♂ | KCH−/− | normal pancreatic tissue | + | - | splenomegaly |
22 | ♀ | KCH−/− | normal pancreatic tissue | + | - | - |
22 | ♂ | KCH−/− | ADM; PanIN-1 | + | - | - |
28 | ♀ | KCH−/− | ADM; PanIN-1 and 2 | + | - | - |
30 | ♂ | KCH−/− | ADM; PanIN-1, 2, and 3 | + | - | - |
36 | ♂ | KCH−/− | ADM; PanIN-1 and 2 | + | - | - |
43 | ♂ | KCH−/− | ADM; PanIN-1 | + | - | - |
43 | ♂ | KCH−/− | ADM; PanIN-1, rare 2 and 3 | + | - | bladder mass |
43 | ♂ | KCH−/− | ADM; PanIN-1 | + | - | - |
45 | ♀ | KCH−/− | ADM; PanIN-3 | + | + | lung mass |
51 | ♂ | KCH−/− | ADM; PanIN-1 | + | - | - |