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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma

Fig. 3

HSF1 is upregulated in human intrahepatic cholangiocarcinoma preinvasive lesions and metastases. Upper panels: Representative immunohistochemistry of HSF1 protein in a preinvasive lesion (one biliary intraepithelial neoplasia or BilIN specimen is shown here). The lesion exhibits pronounced nuclear immunoreactivity for HSF1. CK19 staining was used as a biliary marker. Lower panels: an iCCA lymph node metastasis displaying pronounced HSF1 nuclear immunolabeling in the tumor metastasis (M) and scattered nuclear positiveness in the lymph node (LN) compartment. CK19 staining was used as a biliary marker. Original magnification: 100x; scale bar: 200 μm. Abbreviations: H&E, hematoxylin and eosin staining

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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