Fig. 6

Illustration of cholesterol uptake mechanisms in ovarian cancer. The illustration highlights central molecular mechanisms that lead to altered cholesterol metabolism in ovarian cancer cells. Abbreviations: LDL (low density lipoprotein), HDL (High density lipoprotein), ABCA1 (ATP-binding cassette transporter A1), ABCG2 (ATP-binding cassette transporter G2), MDR1 (Multidrug Resistance 1), SR-B1 (Scavenger receptor B1), INSIG (Insulin-induced gene 1 protein), SOAT1 (Sterol O-acyltransferase 1), SREBP2 (Sterol regulatory element-binding protein 2), SCAP (SREBP cleavage-activating protein), HMGCR (HMG-CoA reductase)