Fig. 5

Illustration of cholesterol uptake mechanisms in breast cancer. The illustration highlights central molecular mechanisms that confer altered cholesterol metabolism in breast cancer cells. The figure includes mechanisms found in ER-negative, ER-positive and triple negative breast cancer. Abbreviations: LDL (low density lipoprotein), HDL (High density lipoprotein), NPC1 (Niemann-Pick disease, type C1), STARD3 (StAR-related lipid transfer protein 3), MZF1 (Myeloid zinc finger 1), EGFR (Epidermal growth factor receptor), ErbB2 (erythroblastic oncogene B 2)