Fig. 2

Targeting delivery and penetration ability of LA-CMGL in vitro. (a) Targeting delivery of CPT and miR-145 in HepG2 cells observed by CLSM (scale bar = 20 μm). (b) The escape ability of LA-CMGL from lysosomes in HepG2 cells at 1 h and 6 h evaluated by CLSM (scale bar = 10 μm). (c) Co-localization analysis of miR-145 in lysosome and cytoplasm in HepG2 cells. (d) Penetration of LA-CMGL (red) in HepG2 MCSs imaged by CLSM Z-stack scanning after 6 h. The MCSs surface was settled at 0 μm. Scale bar = 10 μm