Table 2 Multivariable Cox proportional hazards regression models on disease-free survival (separate analyses for CF- and EV-miRNA)

CF-miRNA

 miR-135a-5p

-0.005

 miR-29c-3p

0.083

0.056

 miR-877-3p

-0.243

-0.180

 Sex (M vs F)

0.265

0.295

1.34 (0.69–2.60)

0.381

 Age at surgery

0.025

0.027

1.03 (0.98–1.07)

0.216

 pSTAGE (II vs I)

1.032

1.013

2.75 (1.28–5.91)

0.009

 pSTAGE (IIIA vs I)

1.389

1.013

4.23 (2.09–8.53)

 < 0.001

EV-miRNA

 miR-127-3p

-0.089

 miR-1277-3p

-0.223

 miR-136-3p

-0.182

 miR-181a-2-3p

-0.148

-0.053

 miR-182-5p

0.089

0.032

 miR-18a-5p

-0.018

 miR-192-5p

0.208

0.185

 miR-32-5p

0.067

 miR-323b-3p

-0.030

 miR-328-3p

-0.039

 miR-339-3p

0.139

 miR-361-3p

0.034

 miR-3615

-0.208

 miR-370-3p

-0.122

 miR-5187-5p

0.211

 miR-532-3p

-0.200

-0.113

 miR-589-5p

-0.054

-0.008

 miR-628-5p

-0.039

 miR-6852-5p

-0.018

 miR9-5p

0.039

 miR-99b-5p

-0.109

 Sex (M vs F)

0.115

0.178

1.20 (0.61–2.32)

0.599

 Age at surgery

0.008

0.011

1.01 (0.97–1.06)

0.611

 pSTAGE (II vs I)

0.988

0.933

2.54 (1.16–5.54)

0.019

 pSTAGE (IIIA vs I)

1.566

1.494

4.46 (2.18–9.10)

 < 0.001