Table 1 Clinical trials evaluating circulating biomarkers in pancreatic cancer
Circulating Biomarkers | ||||||||
|---|---|---|---|---|---|---|---|---|
Classification | Description | Type of sample | Conditions | Enrollment | Status | Trail number | Results/Trial titles | PMID |
Arise from TIME-TIMaE cross-talk | CXCR2 Ligands/CXCR2 Biological Axis Amphoteric regulatory protein (AREG) Metabolome, metabolomic fingerprint Metabolomic fingerprint | blood| tissue| cystic fluid serum blood blood | healthy|Chronic pancreatitis|PC healthy|PC pancreatitis| cystic fibrosis| PC withPancreatic Exocrine Insufficiency high risk|PC | 200 600 150 2522 | COMPLETED UNKNOWN RECRUITING RECRUITING | NCT00851955 NCT04549064 NCT05980221 NCT04164602 | no results no results no results no results | PMID: 33,444,177 |
Behind the TIME TIMaE cross-talk | sTRA and CA19-9 expression Elastase 1 sCD58 and TGFb1, alone or in combination with CA19-9 a consensus signature consisting of 29 biomarkers ctDNA for the diagnosis of early stage PC methylation-specific PCR of a 28 gene panel methylated DNA marker cfDNA methylation cfDNA methylation, serum protein markers, blood miRNA markers cfDNA methylation miRNA profile CIRcular and Non-coding RNAs microRNA-25 Circulating Extracellular Exosomal Small RNA | plasma serum serum serum blood|cyst fluid plasma blood| stool| pancreas cyst fluid| pancreas juice blood blood blood blood blood serum blood | healthy|PC healthy|high risk PDAC|PDAC healthy|pancreatitis|early lesions|PDAC healthy|early lesions|PDAC healthy|pancreatitis|early lesions|PDAC healthy|pancreatitis|PDAC healthy| early lesions healthy| early lesions|PC early lesions |PC healthy|high risk| early lesions|PC healthy| early lesions|PC healthy|pancreatitis|early lesions|PDAC healthy| early lesions|PC healthy| early lesions|PC | 300 2100 2000 5000 750 330 800 276 450 7062 200 186 750 102 | RECRUITING RECRUITING RECRUITING RECRUITING RECRUITING UNKNOWN RECRUITING NOT_YET_RECRUITING RECRUITING RECRUITING RECRUITING UNKNOWN NCT03432624 RECRUITING | NCT04143152 NCT06041009 NCT05500027 NCT03311776 NCT03334708 NCT02079363 NCT03855800 NCT06166147 NCT05495685 NCT05556603 NCT04406831 NCT04584996 NCT03432624 NCT04636788 | sTRA is a validated serological biomarker of PDAC that yields improved performance over CA19-9 no results no results a biomarker signature was created, discriminating samples derived from patients with stage I and II from those from controls with a receiver operating characteristic area under the curve value of 0.96. no results A diagnostic prediction model (age  > 65, BMP3, RASSF1A, BNC1, MESTv2, TFPI2, AP C, SFRP1 and SFRP2) no results no results no results no results no results no results no results no results | PMID: 30,617,132 PMID: 34,168,659 PMID: 30,106,639 |