Fig. 6

Increased accumulation of mitochondrial ROS and oncometabolites in PDLIM2 knockdown lung cancer cells. A, B Mitochondrial ROS in control and PDLIM2 knockdown LLC (A) and A549 (B) lung cancer cells was analyzed by flow cytometry using the MitoSOX Red probe. C, D Analysis of metabolite levels in PDLIM2 knockdown LLC (C), A549 (D) cells and their corresponding controls by LC–MS. Data represent means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 compared with the shEmpty group