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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer

Fig. 8

Graphical representation of ILK-Fzd7-mediated OCSC survival and spheroid formation. Fzd7 receives inputs from the ECM and in turn translates a complex “outside in” signaling through ILK/AKT axis that both amplifies the proliferative Wnt/β-catenin pathway and regulates cell survival. ILK inhibition through cpd-22 disrupts both the proliferative and pro-survivals inputs, thus sensitizing OCSCs to platinum and blocking OC progression

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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