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Table 1 List of the leading-edge genes over-expressed in prostate CAFs, corresponding encoded protein, regulated cation and antiarrhythmic drugs used to block them

From: Repositioning of antiarrhythmics for prostate cancer treatment: a novel strategy to reprogram cancer-associated fibroblasts towards a tumor-suppressive phenotype

Gene

Protein

Cation

Antiarrhythmic

CACNA1H

Cav.3.2

Ca2+

verapamil

nifedipine

CACNB1

CaB1

CACNB2

CaB2

CACNB3

CaB3

KCNS3

Kv9

K+

amiodarone

KCNH2

hERG1.3

KCNQ2

Kv7.2

SCN1B

NaB1

Na+

flecainide

SCN2A

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