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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Repositioning of antiarrhythmics for prostate cancer treatment: a novel strategy to reprogram cancer-associated fibroblasts towards a tumor-suppressive phenotype

Fig. 2

Activated fibroblasts show increased membrane conductance for potassium, sodium and calcium. a Representative Voltage-clamp recordings of inward and outward currents from activated and control WPMY-1 cells fibroblasts. A schematic of the applied protocol is shown in the insert. Upon activation, an inward current as well as a fast-inactivating outward current can be detected in fibroblasts. b The inward current shows significant sensitivity to both flecainide (2.5 μM) and nifedipine (2.5 μM) when applied to the bath solution. c Pie chart summarizing the percentage of cells expressing the main currents detected in A upon depolarization in both the control and the activated group. d The IV plot for the K + steady shows a significant increase in the current density in the activated group compared to the control condition. The I-V plot for the inward current is also displayed

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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