Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence

Table 1 DDX5 interacting proteins implicated in the DNA damage response identified in PCa cell lines versus normal prostatic cell line PNT1A^b

Proteins	LNCaP	DU-145	PC-3	DDR-related pathways
XRCC6		x	x	NHEJ^a
XRCC5		x	x	NHEJ
GTF2H4		x	x	NER
GTF2H1		x	x	NER
ERCC3		x	x	NER
GTF2H2		x	x	NER
GTF2H3		x	x	NER
RFC5	x	x	x	NER
UPF1		x	x	Unclear
PRPF19		x	x	NER, NHEJ
IGHMBP2		x	x	Unclear
MSH6	x	x		MR
TP53		x		BER, NER, DSBR, mitochondrial DNA repair
LIG3		x		BER, NER, alNHEJ, HR, mitochondrial DNA repair
RFC3		x		NER
ERCC2		x		NER
ERCC6			x	NER
RFC1			x	NER
TOP2A			x	DDR
RECQL4			x	HR
MRPS26			x	Mitochondrial DNA repair
MRPS35			x	Mitochondrial DNA repair
DTX3L			x	NHEJ

^aDDR DNA damage response, DSBR double-strand break repair, NHEJ non-homologous end joining, HR homologous recombination, MR mismatch repair, BER base excision repair, NER nucleotide excision repair, alNHEJ alternative NHEJ
^bAdapted from Le et al., Mol Ther. 2023 Feb 1; 31(2):471–486

ISSN: 1756-9966