Fig. 6

A DDX5 is involved in intestinal inflammation to course colitis and tumorigenesis: B1 DDX5 inhibits lipid and protein metabolism in intestine tuft cells by blocking the expression of genes involved in transmembrane transport and lipid metabolism. B2 High succinate results in tuft cell hyperplasia, which leads to ileitis as well as tumorigenesis. B3 DDX5 promotes Wnt signaling, angiogenesis and integrin signaling, while suppressing transmembrane transport, cytokine signaling and metabolism in cancer cells and high succinate could mimic DDX5’s such effects and roles, which will need further investigation