Fig. 4

DDX5 plays a role in cancer metabolic control: A DBP2, a DDX5 yeast ortholog, promotes glucose-dependent gene expression and upregulates the expression levels of HXTs. B1 DDX5 or DBP2 is required for efficient glucose import. B2 DDX5 promotes glycolysis. C DDX5 recruiting with UCP2 at least partially contributes to the metabolic plasticity of NSCLCs via the AKT/mTOR pathway. D CSN6-mediated induction of PHGDH and metabolic reprogramming relies on DDX5, specifically, the E3 ligase β-Trcp interacts with, ubiquitinates and degrades DDX5, which can be blocked by CSN6 to stabilize DDX5 protein and in turn promote DDX5-mediated PHGDH mRNA stabilization, leading to metabolic reprogramming in CRC cells thus, promoting tumorigenesis reflected by poor CRC patient prognosis