Fig. 10

DDX5 mRNA levels are upregulated in PCa and correlate with tumor grade: A, B Increased DDX5 mRNA levels in human PCa. Shown are DDX5 mRNA levels in two different tumor-normal (N) comparisons from the TCGA-PRAD dataset, i.e., 422 treatment-naive PCa (Pri-PCa; A) and 495 total PCa patients in PRAD which includes the 422 Pri-PCa as well as PCa treated with hormone therapy [71] and chemotherapy [2]. **P < 0.01 (Student’s t-test). C Increasing DDX5 mRNA levels in human PCa correlate with tumor grade as indicated by increasing Gleason Scores (GS). DDX5 mRNA levels and corresponding PCa patients’ tumor grade were extracted from UCSC Xena database (http://xena.ucsc.edu/). Data is presented as mean ± SD. Statistical analyses were performed using GraphPad Prism software or using R. Student’s t-test was used to compare PCa of various grades to N while Jonckheere-Terpstra’s trend (J-T) test was used to calculate the statistical significance of the trend across all different groups. *P < 0.05; **P < 0.01; **** P < 0.0001